Chromatography LC/MS

Liquid chromatography with mass spectrometry coupling (LC/MS, HPLC-MS) is an analytical method for the separation and determination of molecules by a combination of liquid chromatography (LC, or HPLC) with mass spectrometry (MS).¨The chromatography is used to separate molecules in a mixture and the subsequent mass spectrometry is used to identify and/or quantify the substances. As a rule, additional detectors are interposed in LC, such as UV/VIS or conductivity detectors.