Supercritical or supercritical fluid chromatography (SFC) is an analytical detection method in chromatography. SFC uses mobile phases that are beyond the substance-specific critical temperature and pressure. Many physical properties of such fluids lie between those of gases and liquids. Of particular note are density, viscosity, and diffusion coefficient. Thus, supercritical fluid chromatography can be used to treat analytical problems for which gas or liquid chromatography are no longer applicable.
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