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MS - Orbi Trap Mass spectrometer

Orbitrap mass spectrometers are high-resolution instruments for mass spectrometry. They use an electrostatic field for precise analysis of mass-to-charge ratios.

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MS - Orbi Trap Mass spectrometer

Orbitrap mass spectrometers are high-resolution instruments for mass spectrometry. They use an electrostatic field for precise analysis of mass-to-charge ratios.

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Highlights

All Highlights

Guide and selection support

Orbitrap mass spectrometers are used for high-resolution analysis of molecules in research and industry, especially in proteomics, environmental analysis, and material testing. The choice of an Orbitrap MS instrument depends on required resolution, mass range, and compatibility with sample preparation methods. LabFinder supports your search and selection of suitable Orbitrap mass spectrometers with clear categorization and detailed device information.

Applications and Benefits

Orbitrap mass spectrometers are specialized ion trap mass spectrometers used for precise analyses in mass spectrometry. Typical applications include qualitative and quantitative analysis of complex samples, such as in protein research, environmental analysis, as well as material and food testing.

The instrument operates without a magnetic field and instead uses an electrostatic field to generate stable ion orbits, enabling high mass resolution and mass accuracy.

Selection Criteria

When selecting an Orbitrap mass spectrometer, users should particularly consider the required mass resolution, the mass-to-charge ratio (m/z) of the material to be analyzed, compatibility with existing sample preparation techniques, and the necessary interfaces for data evaluation. The user-friendliness of the software and integration into existing laboratory systems also play a role.

Variants and Measurement Principles

Orbitrap mass spectrometers are characterized by their innovative electrostatic principle, where ions orbit radially around a central electrode and oscillate axially in an ion trap. The oscillation frequency is converted to mass-to-charge ratios via Fourier transformation. This principle covers a broad mass range with high resolution and does not require complex cooling, unlike magnet-based systems such as FT-ICR-MS.

Calibration and Maintenance

Calibration is performed regularly using standardized reference substances to ensure mass accuracy. Maintenance measures include checking and cleaning the ion optics and detectors, as well as replacing wear parts. The electrostatic design promotes durable and stable performance with manageable maintenance requirements.

Application Limitations

Orbitrap mass spectrometers are designed for high-resolution analyses; however, their dynamic measurement range can be limited compared to other MS types. Samples must be ionizable, and appropriate sample preparation methods often require experience for optimal results. The instruments are technically complex and require skilled personnel for operation.

Search Terms and Related Terms

Orbitrap, OrbiTrap MS, Orbitrap mass spectrometer, ion trap, Fourier transformation, mass spectrometry, high resolution, electrostatic field, mass-to-charge ratio, Orbitrap MS analyzer.

Also known as

High-resolution Orbitrap mass spectrometer Orbitrap ion trap mass spectrometer Orbitrap ion trap MS Orbitrap mass spectrometer OrbiTrap mass spectrometry OrbiTrap MS Orbi Trap MS Orbitrap MS analyzer OrbiTrap MS instrument Orbitrap technology mass spectrometer

Frequently asked questions

How does an Orbitrap mass spectrometer work?

An Orbitrap mass spectrometer uses an electrostatic field where ions orbit and oscillate around a central electrode. The frequency of this oscillation is converted into mass-to-charge ratios using Fourier transformation.

What types of samples can be analyzed with Orbitrap MS?

Orbitrap MS can analyze ionizable samples from fields such as proteomics, environmental analysis, material testing, and food chemistry, with sample preparation methods varying depending on the analysis technique.

What are important selection criteria for Orbitrap mass spectrometers?

Key criteria include the required mass resolution, mass-to-charge ratio range, compatibility with sample preparation, software integration, and ease of operation.

How is an Orbitrap mass spectrometer calibrated and maintained?

Calibration is performed with reference substances to ensure mass accuracy. Maintenance includes cleaning and checking the ion optics as well as replacing wear parts.

What are the limitations of Orbitrap mass spectrometers in application?

Orbitrap MS require ionizable samples and are technically complex. Their dynamic measurement range may be limited compared to other MS types, and they require trained personnel for operation.

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