MS - Orbitrap GC HRMS
MS - Orbitrap GC HRMS combines gas chromatography with high-resolution mass spectrometry based on Orbitrap technology. These systems enable precise qualitative and quantitative analysis of complex samples.
Product
MS - Orbitrap GC HRMS
MS - Orbitrap GC HRMS combines gas chromatography with high-resolution mass spectrometry based on Orbitrap technology. These systems enable precise qualitative and quantitative analysis of complex samples.
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Guide and selection support
MS - Orbitrap GC HRMS is primarily used in analytical laboratories requiring high-resolution separation and mass spectrometry for volatile and semi-volatile compounds. Typical application areas include environmental analysis, food and material testing, as well as pharmaceutical research.
When selecting Orbitrap GC HRMS systems, criteria such as mass accuracy, resolution, detection limits, compatibility with various sample preparation methods, and integration options into existing GC systems are crucial. Ease of use and maintenance requirements are also important considerations.
LabFinder provides users with an objective overview of application areas, technical features, and selection criteria, making it easy to find suitable products and compare technical specifications for targeted laboratory equipment procurement.
Application and Benefits
The MS - Orbitrap GC HRMS is a combination of gas chromatography (GC) for separating complex mixture components and high-resolution Orbitrap mass spectrometry (HRMS) for their precise identification and quantification. It is particularly suitable for the analysis of volatile and semi-volatile organic compounds in environmental samples, food matrices, petrochemicals, and pharmaceutical research.
Thanks to the high mass accuracy and resolution of Orbitrap technology, it is possible to distinguish isobaric compounds and detect trace elements. This improves specificity compared to conventional GC-MS and broadens the range of applications to complex samples that require comprehensive characterization.
Selection Criteria
The most important criteria when selecting an MS - Orbitrap GC HRMS system are resolution, mass accuracy, and sensitivity. Compatibility with existing gas chromatography systems as well as available interfaces for workflows and software integration are important for laboratory implementation.
Additional factors include ease of maintenance, availability of calibration standards and service options, as well as flexibility regarding sample preparation and throughput. The choice of device also depends on the specific application and required detection limits.
Variants and Measurement Principles
The Orbitrap GC HRMS combines the separation power of gas chromatography with the high-resolution mass spectrometry of Orbitrap technology. Here, the ionized substance is analyzed in an Orbitrap mass spectrometer by means of electromagnetic ion trapping, enabling precise mass determination and high resolution.
Variants mainly differ in how they couple with various GC systems, the achievable mass resolution, and the mass spectrometer designs. Most systems also integrate tandem MS capabilities (MS/MS) for even more detailed structural analysis through fragmentation studies.
Calibration and Maintenance
Regular calibration is necessary to ensure the high mass accuracy of the Orbitrap GC HRMS. This involves using internal or external calibration standards that meet mass accuracy and resolution requirements.
Maintenance tasks include cleaning of GC injectors, replacement of wear parts, and checking the vacuum systems and ion sources. A routine maintenance plan ensures long-term stability and measurement quality.
Limitations of Application
MS - Orbitrap GC HRMS is mainly suitable for volatile and thermally stable substances, due to its coupling with gas chromatography. Thermally unstable or highly polar compounds are difficult to analyze and may require alternative methods.
The high complexity of measurement data requires specialized evaluation expertise. In addition, acquisition and operating costs are comparatively high, making this technology especially interesting for specialized analytical applications.
Search Terms and Related Terms
Orbitrap GC HRMS, Orbitrap GC-HRMS, Orbitrap High-Resolution GC-MS, Orbitrap GC-MS HRMS, Gas Chromatography Orbitrap, HRMS Gas Chromatography Orbitrap, Mass Spectrometer Orbitrap GC, Orbitrap GC MS Analyzer, GC HRMS Orbitrap, Orbitrap GC High Resolution Mass Spectrometer, Gas Chromatography, Mass Spectrometry, High-Resolution Mass Spectrometry, GC-MS, Chromatography, Analytics, Spectrometry, Tandem MS.
Also known as
Gas Chromatography Orbitrap
GC HRMS Orbitrap
HRMS Gas Chromatography Orbitrap
Mass Spectrometer Orbitrap GC
Orbitrap GC-HRMS
Orbitrap GC-MS HRMS
Orbitrap GC High Resolution Mass Spectrometer
Orbitrap GC HRMS
Orbitrap GC MS Analyzer
Orbitrap High-Resolution GC-MS
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Frequently asked questions
How does an MS - Orbitrap GC HRMS work?
The MS - Orbitrap GC HRMS combines gas chromatography for substance separation with a high-resolution Orbitrap mass spectrometer, which precisely determines molecular masses. Ionization of the substances typically occurs via electron impact, after which the ions are stored and analyzed in the Orbitrap.
What types of samples can be analyzed with Orbitrap GC HRMS?
Mainly volatile and semi-volatile organic compounds from environmental samples, food, pharmaceutical products, or petrochemical materials can be analyzed using Orbitrap GC HRMS, provided that the substances are thermally stable and compatible with gas chromatography.
What selection criteria are relevant when purchasing an Orbitrap GC HRMS system?
Key criteria include mass accuracy, resolution, sensitivity, compatibility with existing GC systems, user convenience, as well as maintenance requirements and service options. Sample diversity and analysis speed should also be considered.
What are the limitations of using Orbitrap GC HRMS?
The method is limited in analyzing thermally unstable or highly polar compounds that cannot be efficiently separated by gas chromatography. Furthermore, the complex data requires specialized evaluation skills, and the instrument costs are comparatively high.
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